Damas J
J Pharmacol. 1983 Oct-Dec;14(4):449-63.
We studied the hypotensive effect of three carrageenans and of dextran sulphate in Brown Norway (BN) rats. The plasma of these BN rats is devoid of high molecular weight kininogen and poor in plasma prekallikrein. The hypotensive effect in BN rats was greatly reduced in comparison with the effects in normal rats. It was proportional to the thrombocytopenia induced by the sulphated polysaccharides and absent in rats made thrombopenic by antiplatelet serum. The hypotensive effect in BN rats was reduced by bromophenacyl bromide, mepacrine, aspirin, methysergide, promethazine and CCI 17810, and was unchanged after the administration of cobra venom factor, heparin, amino caproic acid, chloroquine, dexamethazone, lidocaine, propranolol, indomethacin, phenidone, imidazol, adenosine and cyproheptadine. The thrombopenic effect was reduced by methysergide and CCI 17810 and was not modified by bromophenacyl bromide and chloroquine.
我们研究了三种角叉菜胶和硫酸葡聚糖对挪威棕色（BN）大鼠的降压作用。这些BN大鼠的血浆中缺乏高分子量激肽原，血浆前激肽释放酶含量也很低。与正常大鼠相比，BN大鼠的降压作用大大降低。它与硫酸化多糖诱导的血小板减少成比例，而在抗血小板血清导致血小板减少的大鼠中则不存在。BN大鼠的降压作用可被溴苯甲酰溴、米帕林、阿司匹林、甲基麦角新碱、异丙嗪和CCI 17810降低，在给予眼镜蛇毒因子、肝素、氨基己酸、氯喹、地塞米松、利多卡因、普萘洛尔、吲哚美辛、苯茚酮、咪唑、腺苷和赛庚啶后无变化。甲基麦角新碱和CCI 17810可降低血小板减少作用，而溴苯甲酰溴和氯喹则不会改变该作用。
