Di Carlo V
Neurosci Lett. 1983 Dec 30;43(2-3):119-25. doi: 10.1016/0304-3940(83)90174-x.
In the lumbar segment of the spinal cord, serotonin-containing nerve fibers are shown to connect the descending serotoninergic pathway of the intermediolateral column with the ipsilateral dorsal root. This may suggest that efferent serotoninergic fibers, originating from brainstem raphe nuclei, leave the spinal cord via the dorsal roots. However, when tryptophan pretreatment is employed in addition to a monoamine oxidase inhibitor, a limited number of yellow-fluorescing neurons can at times also be visualized in the dorsal ganglia. These could be the cell bodies of origin of at least some of the above-mentioned serotonin-containing nerve fibers, which would then have, at least in part, an afferent, sensory function. At present, therefore, the origin and function of this newly discovered serotoninergic pathway remains to be clarified.
在脊髓腰段，含5-羟色胺的神经纤维显示出将中间外侧柱的下行5-羟色胺能通路与同侧背根相连。这可能表明，源自脑干中缝核的传出5-羟色胺能纤维经背根离开脊髓。然而，当除单胺氧化酶抑制剂外还采用色氨酸预处理时，有时在背根神经节中也能看到数量有限的发出黄色荧光的神经元。这些可能是上述至少部分含5-羟色胺神经纤维的起源细胞体，那么这些纤维至少部分具有传入感觉功能。因此，目前这条新发现的5-羟色胺能通路的起源和功能仍有待阐明。
