Tu T, Tu A T, Lin T S
J Pharm Pharmacol. 1976 Feb;28(2):139-45. doi: 10.1111/j.2042-7158.1976.tb04112.x.
The effects of the crude venom, four partially purified venom fractions and pure toxin (Pelamis toxin alpha) from yellow-bellied sea snake, Pelamis platurus, on respiration, blood pressure, heart and skeletal muscle of rabbits have been examined. Results indicated that crude venom, a partially purified toxic fraction and Pelamis toxin alpha caused initial respiratory stimulant effects followed by respiratory paralysis. In most cases, respiratory paralysis occurred before a profound fall in arterial pressure. Depression of the twitch response to nerve stimulation was observed in the tibialis anterior muscle. No significant change in the electrocardiogram was seen. Three partially purified non-toxic fractions of the crude venom induced transient respiratory stimulant effects. It was concluded that the crude venom and Pelamis toxin alpha had an identical mode of action and that they caused respiratory paralysis in rabbits.
对黄腹海蛇（Pelamis platurus）的粗毒、四个部分纯化的毒液组分和纯毒素（黄腹海蛇毒素α）对家兔呼吸、血压、心脏和骨骼肌的影响进行了研究。结果表明，粗毒、一个部分纯化的毒性组分和黄腹海蛇毒素α引起最初的呼吸兴奋作用，随后是呼吸麻痹。在大多数情况下，呼吸麻痹发生在动脉压显著下降之前。在胫前肌中观察到对神经刺激的抽搐反应受到抑制。心电图未见明显变化。粗毒的三个部分纯化的无毒组分引起短暂的呼吸兴奋作用。得出的结论是，粗毒和黄腹海蛇毒素α具有相同的作用模式，并且它们会导致家兔呼吸麻痹。
