Templeton J F, Jackson C C
Steroids. 1983 Aug;42(2):115-21. doi: 10.1016/s0039-128x(83)90144-7.
17 alpha-Methyltestosterone and the reduced metabolites, 17 alpha-methyl-5 alpha-androstane-3 alpha, 17 beta-diol, 17 alpha-methyl-5 alpha-androstane-3 beta, 17 beta-diol and 17 alpha-methyl-5 beta-androstane-3 alpha, 17 beta-diol, together with three hydroxylated metabolites, 17 alpha-methyl-5 beta-androstane-3 alpha, 16 alpha, 17 beta-triol, 17 alpha-methyl-5 beta-androstane-3 alpha, 16 beta, 17 beta-triol and a new metabolite, 17 alpha-methyl-5 alpha-androstane-3 beta, 6 alpha, 17 beta-triol, were isolated and identified in the urine of rabbits dosed with 17 alpha-methyltestosterone. No hydroxylated 5 alpha-metabolite of 17 alpha-methyltestosterone has been identified previously. No of 17 alpha-methyltestosterone has been identified previously. No evidence for epimerization at the C-17 position was observed.
给兔子注射17α-甲基睾酮后，在其尿液中分离并鉴定出了17α-甲基睾酮及其还原代谢产物，即17α-甲基-5α-雄甾烷-3α,17β-二醇、17α-甲基-5α-雄甾烷-3β,17β-二醇和17α-甲基-5β-雄甾烷-3α,17β-二醇，以及三种羟基化代谢产物，即17α-甲基-5β-雄甾烷-3α,16α,17β-三醇、17α-甲基-5β-雄甾烷-3α,16β,17β-三醇和一种新的代谢产物17α-甲基-5α-雄甾烷-3β,6α,17β-三醇。此前尚未鉴定出17α-甲基睾酮的羟基化5α-代谢产物。此前也未鉴定出17α-甲基睾酮的[此处原文似乎不完整]。未观察到C-17位差向异构化的证据。
