Priimiagi L S, Iyks S R, Kul'berg A Ia
Biull Eksp Biol Med. 1978 Mar;85(3):314-6.
Newborn albino mice were inoculated with enteroviruses and in 6 weeks reinfected with homologous or heterologous strains. Strains moderately pathogenic for newborn mice led to formation of specific immunologic memory. Mice infected after birth with highly pathogenic strains produced specific antibodies for a long time and lacked secondary response. Production of interferon was not associated either with the strain pathogenicity for newborn mice or with the presence of antibodies.
将新生白化小鼠接种肠道病毒,6周后再用同源或异源毒株进行感染。对新生小鼠具有中等致病性的毒株可导致特异性免疫记忆的形成。出生后感染高致病性毒株的小鼠长时间产生特异性抗体且缺乏二次反应。干扰素的产生与毒株对新生小鼠的致病性或抗体的存在均无关。