Metabolism of tetraorganolead compounds by rat-liver microsomal mono-oxygenase. I. Analytical methods for quantitative determination of dealkylation products.

Different methods have been examined for the separation and determination of the triethyl lead ion in the presence of tetraethyl lead in biological material. Quantitative recovery of triethyl lead, and a limit of detection of less than 10(-8)M, were obtained with selective chromatography on kieselguhr (Extrelut) in combination with atomic absorption spectrometry.