Van Stratum M, Levarlet M, Lambilliotte J P, Lignian H, de Rood M
Acta Anaesthesiol Belg. 1983 Dec;34(4):233-40.
Labetalol, an alpha and beta adrenergic blocking drug, was used during anesthesia for removal of a very large pheochromocytoma which was predominantly epinephrine secreting. The 70-year-old female patient suffered from angina pectoris and chronic bronchitis. A preoperative treatment including an alpha-adrenolytic drug was administered but beta-adrenergic blockers were avoided because of the risk of cardiac decompensation and bronchoconstriction. During the operation, hypertensive peaks were easily controlled by bolus injections of labetalol 20 mg. The removal of the tumor was followed by a transient moderate hypotension. Heart rate remained stable throughout the operation. No hemodynamic problems occurred during the postoperative period. With regard to this case, a summary of the literature concerning the properties of labetalol is presented.
拉贝洛尔是一种α和β肾上腺素能阻断药物，在麻醉期间用于切除一个非常大的、主要分泌肾上腺素的嗜铬细胞瘤。这位70岁的女性患者患有心绞痛和慢性支气管炎。术前给予了包括α-肾上腺素能阻断药物在内的治疗，但由于存在心脏代偿失调和支气管收缩的风险，未使用β-肾上腺素能阻滞剂。手术期间，通过静脉推注20毫克拉贝洛尔可轻松控制高血压峰值。肿瘤切除后出现了短暂的中度低血压。整个手术过程中心率保持稳定。术后期间未出现血流动力学问题。关于该病例，本文对有关拉贝洛尔特性的文献进行了总结。
