Inoue A, Hara T, Deguchi T
Jpn J Antibiot. 1983 Nov;36(11):3262-7.
The pharmacokinetics of micronomicin (MCR) were studied in dogs after intramuscular (i.m.) and drip intravenous (d.i.v., 0.5, 1 and 2 hours) administration (10 mg/kg). After i.m. administration, the plasma levels of MCR followed a one-compartment open model, and after d.i.v. administration it followed a two-compartment open model. The peak plasma levels of MCR after i.m., 0.5, 1 and 2 hours d.i.v. administration were 28.7 +/- 6.5, 36.7 +/- 3.6, 30.2 +/- 5.1 and 20.3 +/- 2.3 mcg/ml, respectively. The pharmacokinetic parameters (T1/2, AUC, Kel, Vd and Cl) of MCR except Cmax and Tmax were not differentiated by the route of administration. Urinary recovery of MCR after d.i.v. administration was equal to that of MCR after i.m. administration.
在犬体内研究了小诺米星（MCR）在肌内注射（i.m.）和静脉滴注（d.i.v.，0.5、1和2小时）给药（10mg/kg）后的药代动力学。肌内注射给药后，MCR的血浆浓度符合一室开放模型，静脉滴注给药后符合二室开放模型。肌内注射、静脉滴注0.5小时、1小时和2小时给药后MCR的血浆峰浓度分别为28.7±6.5、36.7±3.6、30.2±5.1和20.3±2.3 mcg/ml。除Cmax和Tmax外，MCR的药代动力学参数（T1/2、AUC、Kel、Vd和Cl）不受给药途径的影响。静脉滴注给药后MCR的尿回收率与肌内注射给药后的相等。
