给黄疸雌性大鼠喂食活性炭可提高胚胎存活率。

Improved embryonic survival in the jaundiced female rat fed activated charcoal.

作者信息

Davis D R, Yeary R A, Lee K

出版信息

Pediatr Pharmacol (New York). 1983;3(2):79-85.

Abstract

The effects of reducing plasma bilirubin concentrations, by feeding activated charcoal, on embryonic survival in the jaundiced female Gunn rat was studied. The feeding of charcoal was effective in reducing plasma bilirubin levels by as much as 40%. Improved embryonic survival was observed in the charcoal-fed female rats in which 58% of the time-mated females were pregnant at necropsy. This was compared to 0% for the control females. Forty-eight percent of the charcoal fed and 7% of the control females that were continuously mated produced a live litter. Necropsy observations showed that 41-58% of the fetuses were in some stage of resorption. These findings support the hypothesis of an adverse bilirubin effect on reproduction in the female Gunn rat. It is suggested that jaundice during pregnancy may result in a risk to the unborn fetus.

摘要

研究了通过喂食活性炭降低血浆胆红素浓度对黄疸雌性冈恩大鼠胚胎存活率的影响。喂食活性炭可有效降低血浆胆红素水平达40%。在喂食活性炭的雌性大鼠中观察到胚胎存活率有所提高，其中58%的定时交配雌性大鼠在尸检时怀孕。相比之下，对照雌性大鼠的怀孕率为0%。持续交配的喂食活性炭的雌性大鼠中有48%产下活仔，而对照雌性大鼠中这一比例为7%。尸检观察表明，41%-58%的胎儿处于某种吸收阶段。这些发现支持了胆红素对雌性冈恩大鼠生殖有不良影响的假说。提示孕期黄疸可能会对未出生胎儿造成风险。