γ-氨基丁酸对楔束核切片制备中神经末梢兴奋性的影响。
Effects of gamma-aminobutyric acid on nerve terminal excitability in a slice preparation of cuneate nucleus.
作者信息
Hayes A G, Simmonds M A
出版信息
Br J Pharmacol. 1978 Jul;63(3):503-7. doi: 10.1111/j.1476-5381.1978.tb07804.x.
Abstract
1 Superfusion of a slice preparation of the rat cuneate nucleus with gamma-aminobutyric acid (GABA) depolarized the afferent nerve fibres and increased their excitability. However, before the depolarization had reached its peak the increased excitability reversed to a decreased excitability, an effect which outlasted the depolarization. 2 Both components of the GABA excitability response were dose-related Cl--dependent and antagonized by bicuculline. 3 Possible mechanisms underlying the sequence of excitability changes are discussed.
摘要
- 用γ-氨基丁酸（GABA）对大鼠楔状核切片标本进行灌流，可使传入神经纤维去极化并增加其兴奋性。然而，在去极化达到峰值之前，增加的兴奋性会逆转至兴奋性降低，且这种效应在去极化后仍持续存在。2. GABA兴奋性反应的这两个成分均与剂量相关且依赖于Cl-，并被荷包牡丹碱拮抗。3. 讨论了兴奋性变化序列背后可能的机制。
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本文引用的文献
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DEPOLARIZATION OF PRESYNAPTIC FIBERS IN THE CUNEATE NUCLEUS.楔束核内突触前纤维的去极化
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PHARMACOLOGICAL STUDIES ON THE PRIMARY AFFERENT DEPOLARIZATION OF THE TOAD SPINAL CORD.蟾蜍脊髓初级传入去极化的药理学研究
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Primary afferent neurones: the ionic mechanism of GABA-mediated depolarization.初级传入神经元：γ-氨基丁酸介导的去极化的离子机制
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Picrotoxin-like action of bicuculline.荷包牡丹碱的印防己毒素样作用。
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Depolarization of dorsal root ganglia in the cat by GABA and related amino acids: antagonism by picrotoxin and bicuculline.γ-氨基丁酸及相关氨基酸对猫背根神经节的去极化作用：印防己毒素和荷包牡丹碱的拮抗作用
Brain Res. 1972 Sep 15;44(1):273-7. doi: 10.1016/0006-8993(72)90383-6.
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The effect of the GABA antagonists bicuculline and picrotoxin on primary afferent terminal excitability.γ-氨基丁酸（GABA）拮抗剂荷包牡丹碱和印防己毒素对初级传入终末兴奋性的影响。
Brain Res. 1972 Aug 11;43(1):171-80. doi: 10.1016/0006-8993(72)90282-x.
7
Gamma-aminobutyric acid: role in primary afferent depolarization.γ-氨基丁酸：在初级传入去极化中的作用
Science. 1972 Jun 2;176(4038):1043-5. doi: 10.1126/science.176.4038.1043.
8
Amino acids and presynaptic inhibition in the rat cuneate nucleus.大鼠楔束核中的氨基酸与突触前抑制
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9
Pharmacological studies on inhibition in the cuneate nucleus of the cat.关于猫楔状核抑制作用的药理学研究。
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J Physiol. 1975 Aug;250(1):85-120. doi: 10.1113/jphysiol.1975.sp011044.
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