犬体内新斯的明和吡啶斯的明的血浆清除率。
Plasma clearance of neostigmine and pyridostigmine in the dog.
作者信息
Baker P R, Calvey T N, Chan K, Macnee C M, Taylor K
出版信息
Br J Pharmacol. 1978 Jul;63(3):509-12. doi: 10.1111/j.1476-5381.1978.tb07805.x.
Abstract
1 The pharmacokinetics of neostigmine and pyridostigmine was studied in conscious dogs by the use of a cross-over design. 2 Both neostigmine and pyridostigmine were cleared from plasma in a biexponential manner. 3 The apparent volume of distribution of pyridostigmine was invariably greater than that of neostigmine, and its fast disposition half-life was approximately three times longer. 4 The whole body clearance and the urinary elimination of pyridostigmine was approximately twice that of neostigmine. 5 The slow disposition half-life of pyridostigmine was approximately three times longer than that of neostigmine, suggesting that the longer duration of action of pyridostigmine is related to the differential clearance of the two quarternary amines from plasma.
摘要
- 采用交叉设计，在清醒犬中研究了新斯的明和吡啶斯的明的药代动力学。2. 新斯的明和吡啶斯的明均以双指数方式从血浆中清除。3. 吡啶斯的明的表观分布容积始终大于新斯的明，其快速处置半衰期约长三倍。4. 吡啶斯的明的全身清除率和尿排泄量约为新斯的明的两倍。5. 吡啶斯的明的缓慢处置半衰期约比新斯的明长三倍，这表明吡啶斯的明作用持续时间较长与这两种季铵盐从血浆中的清除差异有关。
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J Biol Chem. 1961 May;236:1498-500.
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