接近足月妊娠大鼠离体子宫颈和子宫角对药物的机械反应。
Mechanical responses of the isolated cervix and uterine horn of pregnant rats near term to drugs.
作者信息
Hollingsworth M, Isherwood C N
出版信息
Br J Pharmacol. 1978 Jul;63(3):513-8. doi: 10.1111/j.1476-5381.1978.tb07806.x.
Abstract
1 The responses of circularly cut strips of cervix and uterine horn from rats on days 20 and 22 of pregnancy to drugs were compared in vitro. 2 The cervix exhibited similar responses and sensitivities to acetylcholine, bradykinin, prostaglandin (PG) F2alpha (day 20) and isoprenaline (day 20) as did the uterine horn but was less sensitive or responded less consistently to isoprenaline (day 22), oxytocin and PG1. PGE2 was more potent on the cervix (day 20). 3 Before term the relatively inextensible connective tissue of the cervix plus contractions of the smooth muscle would help to prevent foetal expulsion. At term the cervical smooth muscle is sufficiently unresponsive to allow cervical dilatation.
摘要
- 比较了妊娠第20天和第22天大鼠宫颈和子宫角环形切割条在体外对药物的反应。2. 宫颈对乙酰胆碱、缓激肽、前列腺素（PG）F2α（第20天）和异丙肾上腺素（第20天）的反应和敏感性与子宫角相似，但对异丙肾上腺素（第22天）、催产素和PG1的敏感性较低或反应不太一致。前列腺素E2对宫颈（第20天）的作用更强。3. 足月前，宫颈相对不可伸展的结缔组织加上平滑肌的收缩有助于防止胎儿排出。足月时，宫颈平滑肌反应性足够低，从而允许宫颈扩张。
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