Dudkiewicz Z
Probl Med Wieku Rozwoj. 1983;12:332-56.
The author studied the mandibular osteogenesis process in Wistar rats during extrauterine development using macroscopic and microscopic investigations. Macroscopic investigations were carried out on rats aged 1, 5, 10, 20, 30 and 70 days, for establishing changes in the structure of the mandible and its elements, and autoradiographic determination of the sites of increased osteogenetic activity using Cr-51 chromium was obtained. Microscopic investigations were carried out in rats aged 1 and 5 days. The purpose of these investigations was a study of the morphological structure of the mandible, autoradiographic demonstration of the sites of increased cellular proliferation using 3H thymidine in rats aged 1 day, and osseous matrix formation in rats aged 1 and 5 days using 3H proline. The reported investigations showed that the periosteum and perichondrium were the source of mandibular bone formation. Proliferation of the cartilage of the condylar process and coronoid process occurs from the side of the perichondrium covering both these processes. This type of cartilage growth differs from the growth of the cartilage on the anterior part of mandibular corpus which showed additionally evidence of enchondral proliferation of cells. The process of osteogenesis was most active in the mandibular processes, anterior part of the mandibular corpus and the sites of attachments of muscles. This finding is explained as a result of function influence on the growing mandible. The results of macroscopic autoradiography performed with Cr-51 were confirmed by microscopic examinations.
作者通过宏观和微观研究，对Wistar大鼠宫外发育过程中的下颌骨成骨过程进行了研究。对1、5、10、20、30和70日龄的大鼠进行了宏观研究，以确定下颌骨及其组成部分结构的变化，并通过使用铬-51进行放射自显影测定成骨活性增加的部位。对1日龄和5日龄的大鼠进行了微观研究。这些研究的目的是研究下颌骨的形态结构，用3H胸腺嘧啶核苷对1日龄大鼠细胞增殖增加部位进行放射自显影显示，并用3H脯氨酸对1日龄和5日龄大鼠的骨基质形成情况进行研究。所报道的研究表明，骨膜和软骨膜是下颌骨形成的来源。髁突和冠状突软骨的增殖发生在覆盖这两个突起的软骨膜一侧。这种类型的软骨生长不同于下颌体前部软骨的生长，下颌体前部软骨还显示出细胞软骨内增殖的证据。成骨过程在下颌骨突起、下颌体前部和肌肉附着部位最为活跃。这一发现被解释为功能对生长中的下颌骨影响的结果。用铬-51进行的宏观放射自显影结果得到了微观检查的证实。
