惊厥品系（E1）小鼠的毒蕈碱型胆碱能受体

Muscarinic cholinergic receptors of the convulsive strain (E1) mouse.

作者信息

Mori K, Fujita S, Kawaguchi K, Chikami T, Ohno K, Tsuji M, Onishi H, Yamagami S, Kawakita Y

出版信息

Folia Psychiatr Neurol Jpn. 1983;37(3):299-302. doi: 10.1111/j.1440-1819.1983.tb00336.x.

DOI:10.1111/j.1440-1819.1983.tb00336.x

Abstract

The biochemical characteristics of the muscarinic acetylcholine receptors were studied on the E1 strain mouse brain by the binding assay using [3H]1- quinuclidinyl benzylate. Scatchard analyses showed that the receptor density (Bmax) of the hippocampus significantly decreased by 26.4% and the affinity (Kd) increased by 18.8% in E1(+) compared to dd-Y. It is suggested that this hippocampal subsensitivity found in E1(+) mouse might be strain-specific, because repeated megimide convulsions failed to produce the same down regulation.

摘要

使用[3H]1-喹核醇基苯甲酸酯结合试验，在E1品系小鼠脑上研究了毒蕈碱型乙酰胆碱受体的生化特性。Scatchard分析表明，与dd-Y相比，E1(+)小鼠海马体的受体密度（Bmax）显著降低了26.4%，亲和力（Kd）增加了18.8%。提示E1(+)小鼠中发现的这种海马体敏感性降低可能是品系特异性的，因为反复使用美解眠惊厥未能产生相同的下调作用。