[A clinicopathological study of metastasis of lung cancer and metastatic lung cancer].

In a series of 282 resected lung specimens of primary lung cancer and 28 of metastatic lung cancer, an investigation was made on some factors influencing on the metastasis. These factors were blood vessel invasion of tumor cells, lymphoid cell infiltration at the site of vessel invasion and the basement membrane formation around the tumor foci. The relationships between the cumulative survivals and these various factors were realized with the following results. Findings of blood vessel invasion were equally correlated with the prognosis of patients as lymph node metastasis. Among patients with blood vessel invasion, those with prominent lymphoid cell reaction at the site of vessel invasion showed the longer survival than those of negative reaction. The formation of basement membrane, which was thought to be a factor influencing on the prognosis, around tumor cells, were correlated with the blood vessel invasion.