用大花奇峰锦（Burm.f.）Toelken及其一些蟾蜍二烯羟酸内酯在绵羊身上进行krimpsiekte的实验性诱导。
The experimental production of krimpsiekte in sheep with Tylecodon grandiflorus (Burm.f.) Toelken and some of its bufadienolides.
作者信息
Anderson L A, Joubert J P, Prozesky L, Kellerman T S, Schultz R A, Procos J, Olivier P M
出版信息
Onderstepoort J Vet Res. 1983 Dec;50(4):301-7.
PMID:6676693
Abstract
Six bufadienolides were isolated from Tylecodon grandiflorus ( Burm .f.) Toelken . The paretic syndrome, krimpsiekte , could be induced in sheep either by repeated oral administration of small quantities of plant material or the intravenous injection of small quantities of certain bufadienolides . A mild to moderate, acute to subacute, multifocal cardiomyopathy was evident in sheep poisoned by both the plant and the bufadienolides .
摘要
从大花奇峰锦（Tylecodon grandiflorus (Burm.f.) Toelken）中分离出了六种蟾蜍二烯羟酸内酯。无论是通过反复口服少量植物材料，还是静脉注射少量特定的蟾蜍二烯羟酸内酯，都能在绵羊身上诱发轻瘫综合征，即krimpsiekte。在因该植物和蟾蜍二烯羟酸内酯中毒的绵羊身上，明显出现了轻度至中度、急性至亚急性的多灶性心肌病。
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