Dassi E, Boschetti M, Cavenaghi A E, Ciaccio V, Cozzi G, De Carlis L, Del Buono L, Forzinetti E, Galli G, Pissaia L
Quad Sclavo Diagn. 1983 Sep;19(3):360-8.
We have explored the changes of plasma concentrations of antithrombin III and fibrinogen in patients recovering from major abdominal and cardiac surgery. In one group of patients subjected to major abdominal surgery we detected a statistically significant reduction of antithrombin III in the second and third postoperative day, followed by return to normal values in the fourth or fifth day. Fibrinogen, instead, increased to as much as 180% of the preoperative value in the first four postoperative days and reverted slowly to preoperative values between the fourth and the eighth day. In another group of patients subjected to cardiac surgery procedures utilizing the heart-lung machine, however, we found no significant reductions of antithrombin III in the early postoperative period. These results suggest the possible influence of local tissue factors affecting the plasma levels of antithrombin III differently in the two types of surgery under discussion. The patients subjected to extracorporeal circulation, on the other hand, showed a depletion of plasma fibrinogen down to less than 30 or 40% of preoperative values. This may reflect activation of coagulation processes and the considerable sequestration of fibrin at some interfaces of the heart-lung machine.
我们研究了接受腹部大手术和心脏手术的患者术后血浆中抗凝血酶III和纤维蛋白原浓度的变化。在一组接受腹部大手术的患者中，我们发现术后第二天和第三天抗凝血酶III浓度有统计学意义的下降，随后在第四天或第五天恢复到正常值。相反，纤维蛋白原在术后前四天增加到术前值的180%，并在第四天至第八天之间缓慢恢复到术前值。然而，在另一组使用心肺机进行心脏手术的患者中，我们发现在术后早期抗凝血酶III没有显著下降。这些结果表明，在上述两种手术中，局部组织因子可能以不同方式影响抗凝血酶III的血浆水平。另一方面，接受体外循环的患者血浆纤维蛋白原减少至术前值的30%或40%以下。这可能反映了凝血过程的激活以及心肺机某些界面处纤维蛋白的大量沉积。
