[Absorption of protein antigens in the gastrointestinal system of rats and guinea pigs].

The permeability of the gastrointestinal tract of adult rats for 3H-labeled bovine serum albumin (BSA) and 3H-chick albumin (CA) were studied and compared during intragastric administration via a tube. The content of structures with antigenicity of initial proteins was measured in the peripheral blood serum and salt liver extract obtained on homogenate centrifugation. It was found that CA, as compared with BSA, was capable to penetrate the gastrointestinal barrier in a greater amount and to preserve its initial antigenicity, which correlated with a higher resistance to acid denaturation and proteolysis. The permeability of gastrointestinal tract for CA was also examined in rats and guinea-pigs. It was demonstrated that the content of structures having antigenicity of initial CA in the blood serum and liver of rats was significantly higher than in guinea-pigs. It is concluded that this fact is related to the differences in the organization and functioning of the gastrointestinal tract in different animals.