Effects of 5-fluorouracil on 5-fluorodeoxyuridine 5'-monophosphate and 2-deoxyuridine 5'-monophosphate pools, and DNA synthesis in solid mouse L1210 and rat Walker 256 tumors.

Suppr

超能文献

作者信息

Klubes P, Connelly K, Cerna I, Mandel H G

出版信息

Cancer Res. 1978 Aug;38(8):2325-31.

PMID:667828

Abstract

摘要

相似文献

Effects of 5-fluorouracil on 5-fluorodeoxyuridine 5'-monophosphate and 2-deoxyuridine 5'-monophosphate pools, and DNA synthesis in solid mouse L1210 and rat Walker 256 tumors.

Cancer Res. 1978 Aug;38(8):2325-31.

Studies of the antitumor action of 5-fluorouracil (FU).5-氟尿嘧啶（FU）抗肿瘤作用的研究。

Bull Cancer. 1979;66(1):49-54.

A biochemical and pharmacological study of therapeutic synergism with 5-fluorouracil plus cyclophosphamide in murine L1210 leukemia.

Cancer Res. 1979 Apr;39(4):1396-404.

Effects of 5-fluorouracil on human colon carcinoma and solid rat Walker 256 carcinosarcoma: evaluation as in vitro predictors of clinical response.5-氟尿嘧啶对人结肠癌及大鼠实体Walker 256癌肉瘤的作用：作为临床反应体外预测指标的评估

Cancer Treat Rep. 1978 Jul;62(7):1065-73.

The basis for the disparate sensitivity of L1210 leukemia and Walker 256 carcinoma to a new triazine folate antagonist.

Cancer Res. 1973 Nov;33(11):2972-6.

Selectivity of action of 5-FU: biochemical basis.5-氟尿嘧啶作用的选择性：生化基础

Bull Cancer. 1979;66(1):43-7.

Interaction of chemotherapeutic agents with methotrexate and 5-fluorouracil and its effect on de novo DNA synthesis.化疗药物与甲氨蝶呤和5-氟尿嘧啶的相互作用及其对从头DNA合成的影响。

Cancer Res. 1975 Mar;35(3):801-6.

Increased formation of 5-fluoro-2'-deoxyuridine 5'-monophosphate from 5-fluorouracil in the presence of 2-deoxy-alpha-D-ribose 1-phosphate and 2'-deoxyuridine in Ehrlich ascites tumor cells.

Nucleic Acids Symp Ser. 1980(8):s169-72.

Differential cell permeability and the basis for selective activity of methotrexate during therapy of the L1210 leukemia.L1210白血病治疗期间细胞通透性差异及甲氨蝶呤选择性活性的基础。

Cancer Res. 1973 Jun;33(6):1290-4.

The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.5-氟尿嘧啶在荷实体L1210淋巴细胞白血病小鼠体内的生理处置

Cancer Res. 1972 May;32(5):1045-56.

引用本文的文献

Application of artificial neural network to investigate the effects of 5-fluorouracil on ribonucleotides and deoxyribonucleotides in HepG2 cells.应用人工神经网络研究5-氟尿嘧啶对HepG2细胞中核糖核苷酸和脱氧核糖核苷酸的影响。

Sci Rep. 2015 Nov 18;5:16861. doi: 10.1038/srep16861.

Tomudex (ZD1694): from concept to care, a programme in rational drug discovery.拓姆替克（ZD1694）：从概念到医疗，合理药物研发项目

Invest New Drugs. 1996;14(3):305-16. doi: 10.1007/BF00194534.

Effect of concurrent calcium leucovorin infusion on 5-fluorouracil cytotoxicity against murine L1210 leukemia.

Cancer Chemother Pharmacol. 1981;6(2):121-5. doi: 10.1007/BF00262328.

Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.

Cancer Chemother Pharmacol. 1984;13(2):86-90. doi: 10.1007/BF00257120.

5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.5-氟尿嘧啶-甲氨蝶呤协同作用：二氢蝶酰多聚谷氨酸增强5-氟脱氧尿苷酸与胸苷酸合成酶的结合

Proc Natl Acad Sci U S A. 1980 Oct;77(10):5663-7. doi: 10.1073/pnas.77.10.5663.

The validity of the labelling index in tumour studies.肿瘤研究中标记指数的有效性。

Br J Cancer. 1985 Jan;51(1):15-21. doi: 10.1038/bjc.1985.3.

Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil.在培养的L1210细胞中，使用亚叶酸联合序贯甲氨蝶呤和氟尿嘧啶时缺乏增强的细胞毒性。

Cancer Chemother Pharmacol. 1985;15(3):214-9. doi: 10.1007/BF00263888.

Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.使用体内磁共振波谱法测量的氟核苷酸峰积分预测5-氟尿嘧啶对沃克癌肉瘤的细胞毒性。

Br J Cancer. 1989 Sep;60(3):303-9. doi: 10.1038/bjc.1989.275.

An optimized synthesis of 18F-labelled 5-fluorouracil and a reevaluation of its use as a prognostic agent.

Eur J Nucl Med. 1989;15(5):225-9. doi: 10.1007/BF00257538.

Cellular pharmacology of fluorinated pyrimidines in vivo in man.

Invest New Drugs. 1989 Apr;7(1):13-25. doi: 10.1007/BF00178188.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验