Weick J K, Tranum B L, Morrison F S
Invest New Drugs. 1983;1(3):249-51. doi: 10.1007/BF00208898.
L-Alanosine, an antitumor antibiotic was administered by members of the Southwest Oncology Group (SWOG) to 22 patients with resistant acute non-lymphocytic leukemia. The drug was administered by continuous infusion for five days at a starting dose of 125 mg/m2/day. Mucositis was dose-limiting in 15 patients and no marrow aplasia was attained. As administered, L-Alanosine is not an effective single agent in acute leukemia.
L-丙氨菌素，一种抗肿瘤抗生素，由西南肿瘤协作组（SWOG）的成员给予22例耐药急性非淋巴细胞白血病患者。该药物以125毫克/平方米/天的起始剂量持续输注五天。15例患者出现了剂量限制性粘膜炎，未达到骨髓再生障碍。按照所给方式给药时，L-丙氨菌素在急性白血病中不是一种有效的单一药物。
