Hass W K
Neurol Clin. 1983 Feb;1(1):345-53.
The author reviews the major biochemical events that follow in the wake of a significant brain ischemic insult. Evidence is presented that establishes lactic acidosis as a significant accelerant of the ischemic cascade and that proposes that uncontrolled entry of calcium into the vulnerable neuron triggers cell death.
作者回顾了严重脑缺血损伤后随之发生的主要生化事件。有证据表明乳酸酸中毒是缺血级联反应的重要加速因素,并且提出钙不受控制地进入易损神经元会触发细胞死亡。