Jones C E, Smith E E, DuPont E, Williams R D
Circ Shock. 1978;5(2):97-104.
Studies were performed to determine whether or not regions of left ventricle become nonperfused in the normovolemic stages of hemorrhagic shock. Using the endothelial fluorescent stain thioflavin S as a tracer, nonperfused myocardium was assessed in six control dogs, eight dogs in early normovolemic shock, and 15 dogs in late normovolemic shock. Nonperfused myocardium was not demonstrable in any of the control animals and in only one of the early shock animals. However, in nine of the late shock animals, nonperfused myocardium was clearly evident, particularly in the anterior and posterior papillary muscles. The demonstration of nonperfused myocardium in late shock is compatible with the concept of a progressively developing edema with a consequent interruption of blood flow.
开展了多项研究以确定在失血性休克的正常血容量阶段左心室区域是否会出现无灌注情况。使用内皮荧光染料硫黄素 S 作为示踪剂，对 6 只对照犬、8 只处于早期正常血容量休克的犬以及 15 只处于晚期正常血容量休克的犬的无灌注心肌进行了评估。在任何一只对照动物以及仅一只早期休克动物中均未发现无灌注心肌。然而，在 9 只晚期休克动物中，无灌注心肌明显可见，尤其是在前、后乳头肌处。晚期休克中无灌注心肌的出现与逐渐发展的水肿导致血流中断的概念相符。
