Jeynes B J, Gunnlaugson B
Artery. 1983;12(3):156-69.
One of the complications associated with atherothromboembolic lesions is thrombosis. Recent evidence suggests that a non-lipid component of atheroma is intensely thrombogenic. To determine whether other of the embolic components might be thrombogenic, both homologous arterial thrombus material and pure cholesterol crystals were assessed by adding 0.9 mg of thrombus material or an equivalent quantity of crystals to 1 ml aliquots of recalcified rabbit arterial blood in tests designed to measure either clotting times or the size and weight of thrombi experimentally induced in a Chandler tube apparatus. This data was compared to that of comparative saline control conditions. The results indicate that homologous arterial thrombus material is moderately thrombogenic and that cholesterol crystals are not thrombogenic. This study demonstrates that embolizing arterial thrombus material could be contributory to secondary, and thus potentially more injurious, reactions in embolic vascular disease, and that cholesterol crystals appear not to contribute to complicating secondary thrombotic reactions.
与动脉粥样血栓栓塞性病变相关的并发症之一是血栓形成。最近的证据表明，动脉粥样硬化的一种非脂质成分具有强烈的致血栓性。为了确定其他栓塞成分是否可能具有致血栓性，在旨在测量凝血时间或在钱德勒管装置中实验诱导的血栓大小和重量的试验中，通过向1 ml重新钙化的兔动脉血等分试样中加入0.9 mg血栓物质或等量的晶体，对同源动脉血栓物质和纯胆固醇晶体进行了评估。将该数据与比较生理盐水对照条件下的数据进行比较。结果表明，同源动脉血栓物质具有中度致血栓性，而胆固醇晶体不具有致血栓性。本研究表明，栓塞性动脉血栓物质可能促成栓塞性血管疾病中的继发性反应，从而可能造成更大的损害，并且胆固醇晶体似乎不会导致继发性血栓形成反应复杂化。
