Bakker H D, van Gennip A H, Duran M, Wadman S K
Clin Chim Acta. 1978 Jun 15;86(3):349-52. doi: 10.1016/0009-8981(78)90392-3.
In a pregnant woman, who had given birth to a child with methylmalonic acidaemia previously, urinary methylmalonate was measured at various intervals in the second half of the pregnancy. A significant increase was observed towards term. The child proved to be affected. This procedure enabled the detection of an affected fetus in the third trimester of pregnancy. If a case of methylmalonic acidaemia is detected in this way, treatment can be started immediately after birth.
