Milvae R A, Hansel W
J Reprod Fertil. 1983 Jan;67(1):203-7. doi: 10.1530/jrf.0.0670203.
Holstein heifers (4/group) were injected intramuscularly with 0, 5, 10 or 25 mg 13,14-dihydro-PGF-2 alpha on Day 10 of the oestrous cycle. Complete luteolysis and precocious oestrus occurred in 3 of 4 heifers receiving 25 mg and 1 of 4 receiving 10 mg 13,14-dihydro-PGF-2 alpha injected i.m. These features were not affected in heifers injected with 0 or 5 mg 13,14-dihydro-PGF-2 alpha, although plasma progesterone concentrations were depressed in all treated heifers within 75 min. LH concentrations were elevated between 5 and 8 h after 13,14-dihydro-PGF-2 alpha in all treated heifers. The addition of 13,14-dihydro-PGF-2 alpha to dispersed bovine luteal cells did not affect progesterone accumulation during a 2-h period. These results suggest that 13,14-dihydro-PGF-2 alpha may play a role in PGF-2 alpha-induced luteolysis.
在发情周期的第10天，给荷斯坦小母牛（每组4头）肌肉注射0、5、10或25毫克13,14 - 二氢 - PGF - 2α。肌肉注射25毫克13,14 - 二氢 - PGF - 2α的4头小母牛中有3头以及注射10毫克的4头小母牛中有1头出现了完全黄体溶解和早熟发情。注射0或5毫克13,14 - 二氢 - PGF - 2α的小母牛未出现这些特征，不过所有接受治疗的小母牛在75分钟内血浆孕酮浓度均有所下降。所有接受治疗的小母牛在注射13,14 - 二氢 - PGF - 2α后5至8小时LH浓度升高。向分散的牛黄体细胞中添加13,14 - 二氢 - PGF - 2α在2小时内不影响孕酮的积累。这些结果表明，13,14 - 二氢 - PGF - 2α可能在PGF - 2α诱导的黄体溶解中起作用。
