妊娠期间，胎羊血清生长调节素C浓度显著升高。

Serum somatomedin C concentrations in the fetal sheep increase markedly during gestation.

作者信息

Handwerger S, D'Ercole A J, Underwood L E, Gluckman P, Liggins G C

出版信息

J Endocrinol. 1983 Feb;96(2):269-71. doi: 10.1677/joe.0.0960269.

DOI:10.1677/joe.0.0960269

Abstract

Serum somatomedin C concentrations in fetal sheep and pregnant ewes from days 51 to 149 of gestation were determined by specific radioimmunoassay. In the fetus (n = 61 samples) serum somatomedin C concentrations, fitted to a regression curve, increased significantly with advancing gestation from 0.44 units/ml at 51 days to 3.99 units/ml at 149 days, an increase of 806% (P less than 0.001). In the pregnant ewes (n = 14 samples), serum somatomedin C did not change during gestation. The temporal relationship between the marked increase in fetal somatomedin C concentrations and the acceleration of fetal growth is consistent with the hypothesis that somatomedin is important in the stimulation of fetal growth.

摘要

采用特异性放射免疫分析法测定了妊娠51天至149天的胎羊和妊娠母羊血清生长调节素C的浓度。在胎儿（n = 61个样本）中，血清生长调节素C浓度拟合回归曲线后，随着妊娠进展显著增加，从51天时的0.44单位/毫升增至149天时的3.99单位/毫升，增幅为806%（P<0.001）。在妊娠母羊（n = 14个样本）中，血清生长调节素C在妊娠期未发生变化。胎儿生长调节素C浓度的显著增加与胎儿生长加速之间的时间关系与生长调节素在刺激胎儿生长中起重要作用的假设一致。