Cheung N K, Hilgartner M W, Schulman I, McFall P, Glader B E
J Pediatr. 1983 Mar;102(3):366-70. doi: 10.1016/s0022-3476(83)80650-7.
Platelet-associated IgG was studied in children with acute and chronic ITP and in patients with thrombocytopenic SLE, using the microtiter solid-phase radioimmunoassay. Of the children with acute ITP, 85% had elevated PAIgG levels. The degree of elevation of PAIgG at onset of disease did not correlate with the development of chronicity. Of the children with acute ITP, clinically and hematologically indistinguishable from the rest, 15% had normal PAIgG values. All of 22 children with chronic ITP had elevated PAIgG values. Although there was good correlation between the platelet count and the PAIgG value in children with chronic ITP, the association was not as striking in those with acute ITP; thus, factors in addition to the level of PAIgG may contribute to the thrombocytopenia in the latter group. Patients with SLE and thrombocytopenia had higher values of PAIgG than would be predicted from the platelet count; the PAIgG value is probably not the only factor determining the degree of immune thrombocytopenia.
采用微量滴定固相放射免疫分析法，对急性和慢性免疫性血小板减少性紫癜（ITP）患儿以及血小板减少性系统性红斑狼疮（SLE）患者的血小板相关IgG进行了研究。急性ITP患儿中，85%的患者血小板相关IgG（PAIgG）水平升高。疾病发作时PAIgG的升高程度与慢性病程的发展无关。在临床表现和血液学检查与其他患儿无差异的急性ITP患儿中，15%的患者PAIgG值正常。22例慢性ITP患儿的PAIgG值均升高。虽然慢性ITP患儿的血小板计数与PAIgG值之间存在良好的相关性，但在急性ITP患儿中这种关联并不那么显著；因此，除了PAIgG水平外，其他因素可能也导致了后一组患儿的血小板减少。SLE合并血小板减少的患者其PAIgG值高于根据血小板计数所预测的值；PAIgG值可能不是决定免疫性血小板减少程度的唯一因素。
