Gervas J J, Muradás V, Bazán E, Aguado E G, de Yébenes J G
Neurology. 1983 Mar;33(3):278-82. doi: 10.1212/wnl.33.3.278.
We studied the effects of 3-methoxy, 4-hydroxy-phenylalanine (3-OM-dopa) on monoamine turnover, L-3-4-dihydroxy-phenylalanine (L-dopa) reversal of catecholamine depletion induced by alpha-methyl-paratyrosine (alpha-MT), and the passage of L-dopa across the blood-brain barrier of the rat brain. 3-OM-dopa did not affect monoamine turnover but interfered with restoration of dopamine levels by L-dopa. In addition, systemic 3-OM-dopa decreased brain uptake of 14C-L-dopa. High 3-OM-dopa blood levels may interfere with the therapeutic response to L-dopa in parkinsonism.
我们研究了3-甲氧基-4-羟基苯丙氨酸（3-OM-多巴）对单胺周转、左旋多巴（L-多巴）逆转α-甲基对酪氨酸（α-MT）诱导的儿茶酚胺耗竭的影响，以及L-多巴穿过大鼠脑血脑屏障的情况。3-OM-多巴不影响单胺周转，但会干扰L-多巴对多巴胺水平的恢复。此外，全身性的3-OM-多巴会降低脑对14C-L-多巴的摄取。高血药浓度的3-OM-多巴可能会干扰帕金森病患者对L-多巴的治疗反应。
