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胆红素的体外和体内光反应性:I. 激光定义的波长依赖性。

The in vitro and in vivo photoreactivity of bilirubin: I. Laser-defined wavelength dependence.

作者信息

Gutcher G R, Yen W M, Odell G B

出版信息

Pediatr Res. 1983 Feb;17(2):120-3. doi: 10.1203/00006450-198302000-00008.

DOI:10.1203/00006450-198302000-00008
PMID:6681896
Abstract

Monochromatic light was provided by a continuous wave Argon ion laser. We chose to study the in vitro effects of light at 457.9, 465.8, 476.5, 488.0, 501.7, and 514.5 nm as representative of a reasonably evenly spaced sampling across the blue-green spectrum. The in vivo experiments were conducted at 457.9, 476.5, 488.0, and 514.5 nm. In vitro light at 488.0 nm appeared to be more effective than the others studied. After 24 h of irradiance, the in vivo decline in serum bilirubin concentration produced by light at 488.0 nm was one-and-one-half, two, and four times as effective as light at 457.9, 476.5 and 514.5 nm, respectively. By 48 h of exposure, the declines produced by light at 457.9 nm and 488.0 nm are significantly superior to that at 476.5 nm and 514.5 nm, but they do not differ from one another.

摘要

连续波氩离子激光器提供单色光。我们选择研究457.9、465.8、476.5、488.0、501.7和514.5纳米波长的光在体外的效应,这些波长代表了在蓝绿色光谱上相当均匀间隔的采样。体内实验在457.9、476.5、488.0和514.5纳米波长下进行。488.0纳米波长的体外光似乎比所研究的其他波长的光更有效。照射24小时后,488.0纳米波长的光使体内血清胆红素浓度下降的效果分别是457.9、476.5和514.5纳米波长光的1.5倍、2倍和4倍。到照射48小时时,457.9纳米波长和488.0纳米波长的光使血清胆红素浓度下降的效果显著优于476.5纳米波长和514.5纳米波长的光,但这两种波长的光之间没有差异。

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