Scapin F, Calistri D, Tronconi G, Pellicciotta G, Bareggi S R, Pontiroli A E
Gynecol Obstet Invest. 1983;15(3):185-90. doi: 10.1159/000299410.
Metergoline, a prolactin (PRL) lowering drug, is used in the puerperal period to inhibit lactation. Methylergobasine maleate (MEM), widely employed in the puerperium to promote uterine contractions, has also been reported to decrease PRL release and to reduce lactation. To evaluate the possible interactions of the two drugs, groups of 6-11 puerperae each received no treatment, metergoline alone (8 or 12 mg/day for 5 days), MEM alone (0.2 mg i.v. at delivery followed by 0.5 mg/day p.o. for 5 days) and metergoline plus MEM. Metergoline fully prevented lactation and significantly reduced PRL release, the higher dose inducing effects faster. MEM was without effect on PRL release and lactation, and did not modify the effect of metergoline.
美麦角林是一种降低催乳素（PRL）的药物，在产褥期用于抑制泌乳。马来酸甲基麦角新碱（MEM）在产褥期广泛用于促进子宫收缩，也有报道称其可减少PRL释放并减少泌乳。为评估这两种药物可能的相互作用，将每组6 - 11名产妇分别给予不治疗、单独使用美麦角林（8或12毫克/天，持续5天）、单独使用MEM（分娩时静脉注射0.2毫克，随后口服0.5毫克/天，持续5天）以及美麦角林加MEM。美麦角林完全抑制了泌乳并显著降低了PRL释放，较高剂量起效更快。MEM对PRL释放和泌乳无影响，也未改变美麦角林的作用。
