Matsuo Y, Seki A, Yakabi K, Saziki R, Arai I, Isobe Y, Aihara H
Arzneimittelforschung. 1983;33(2):242-3.
Effect of 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy)chalcone (SU-88), a new anti-ulcer drug, on gastric tissue blood flow was investigated by using an inhaled hydrogen gas clearance method in rats. As a result, following the intravenous infusions of 10,20 and 30 mg/kg/h of SU-88, the gastric blood flow increased with an increase rate of 38.1, 70.5 and 61.7% as compared with the control value, respectively. Following the intraperitoneal administrations of 50 and 100 mg/kg of SU-88, the gastric blood flow increased by 59.8 and 51.2%, respectively, immediately after the administration.
采用吸入氢气清除法在大鼠中研究了新型抗溃疡药物2'-羧甲氧基-4,4'-双(3-甲基-2-丁烯氧基)查耳酮(SU-88)对胃组织血流的影响。结果，静脉输注10、20和30mg/kg/h的SU-88后，胃血流量分别比对照值增加了38.1%、70.5%和61.7%。腹腔注射50和100mg/kg的SU-88后，给药后立即胃血流量分别增加了59.8%和51.2%。
