Price L A, Hill B T, Marks P, Howell A, Monypenny I, Morrison J M
Eur J Cancer Clin Oncol. 1983 Jan;19(1):1-4. doi: 10.1016/0277-5379(83)90388-7.
Forty-three patients with metastatic breast cancer were treated with a total of 385 cycles of combination chemotherapy consisting of adriamycin, cyclophosphamide, 5-fluorouracil, methotrexate and vincristine sulphate given over 24 hr and followed by a leucovorin 'rescue'. Thirty patients (70%) responded with three complete remissions. Thirteen patients did not respond, including six in whom the progression of disease was apparently arrested. Duration of response ranged from 2 to 24 months. At 20 months, 10 of 30 responding patients were alive compared with 1 of 13 non-responders. Toxicity was minimal apart from nausea and vomiting. This study confirms previous reports that intensive chemotherapy can be given safely over 24 hr without loss of therapeutic effect. This regimen is now being tested as an adjuvant to mastectomy in node-positive operable breast surgery.
43例转移性乳腺癌患者接受了总共385个周期的联合化疗，化疗方案为阿霉素、环磷酰胺、5-氟尿嘧啶、甲氨蝶呤和硫酸长春新碱，在24小时内给药，随后进行亚叶酸钙“解救”。30例患者（70%）有反应，其中3例完全缓解。13例患者无反应，包括6例疾病进展明显停止的患者。反应持续时间为2至24个月。20个月时，30例有反应的患者中有10例存活，而13例无反应的患者中只有1例存活。除恶心和呕吐外，毒性极小。本研究证实了先前的报道，即强化化疗可在24小时内安全给药而不丧失治疗效果。该方案目前正在作为阳性淋巴结可手术乳腺癌手术中乳房切除术的辅助治疗进行试验。
