Kafetzopoulos E, Papadopoulos G
Behav Brain Res. 1983 May;8(2):217-23. doi: 10.1016/0166-4328(83)90056-6.
Unilateral stereotaxic lesions of the subthalamic nucleus of rats with kainic acid induced a transient spontaneous ipsiversive turning which was present for several days, and which could be blocked by i.p. administration of haloperidol. After the 20th postoperative day, when no spontaneous turning activity was present, i.p. administration of apomorphine or amphetamine in the kainic acid lesioned rats induced ipsiversive turning, while i.p. haloperidol in the same rats induced contraversive turning. These findings suggest that the subthalamic nucleus is involved in the dopaminergic mechanisms mediating turning behavior of rats.
用 kainic 酸诱导大鼠丘脑底核的单侧立体定向损伤会引起持续数天的短暂自发性同侧旋转，腹腔注射氟哌啶醇可阻断这种旋转。术后第 20 天之后，当不存在自发性旋转活动时，给 kainic 酸损伤的大鼠腹腔注射阿扑吗啡或苯丙胺会诱导同侧旋转，而给相同大鼠腹腔注射氟哌啶醇则会诱导对侧旋转。这些发现表明，丘脑底核参与介导大鼠旋转行为的多巴胺能机制。
