Tendera M, Polonski L, Kozielska E
Chest. 1983 Jul;84(1):54-7. doi: 10.1378/chest.84.1.54.
In 16 patients with hypertrophic cardiomyopathy, an acute response of the left ventricular end-diastolic pressure and volume index to intravenously administered verapamil was assessed. Verapamil decreased the left ventricular end-diastolic pressure from 20 +/- 6 to 17 +/- 5 mm Hg(p less than 0.001) and increased the end-diastolic volume index from 82 +/- 22 to 91 +/- 23 ml/sqm (p less than 0.01). In 13 (81 percent) of 16 patients, an improvement of end-diastolic pressure-volume relationships occurred. In hypertrophic cardiomyopathy, intravenous verapamil exerts a beneficial effect on left ventricular filling conditions, producing an augmentation of filling volume at a lower filling pressure.
对16例肥厚型心肌病患者评估了静脉注射维拉帕米后左心室舒张末期压力和容积指数的急性反应。维拉帕米使左心室舒张末期压力从20±6毫米汞柱降至17±5毫米汞柱（p<0.001），并使舒张末期容积指数从82±22毫升/平方米增至91±23毫升/平方米（p<0.01）。16例患者中有13例（81%）舒张末期压力-容积关系得到改善。在肥厚型心肌病中，静脉注射维拉帕米对左心室充盈状况产生有益影响，在较低充盈压力下使充盈量增加。
