大剂量静脉注射纤溶酶裂解的丙种球蛋白治疗成人自身免疫性血小板减少性紫癜。

Treatment of adult autoimmune thrombocytopenic purpura with high-dose intravenous plasmin-cleaved gammaglobulins.

作者信息

Solal-Celigny P, Bernard J F, Herrera A, Boivin P

出版信息

Scand J Haematol. 1983 Jul;31(1):39-44. doi: 10.1111/j.1600-0609.1983.tb02134.x.

DOI:10.1111/j.1600-0609.1983.tb02134.x

Abstract

We present the results of the treatment of 15 adult patients with chronic autoimmune thrombocytopenic purpura with high dose i.v. gammaglobulins. In 11 patients, this treatment produced a remission, complete (platelet counts above 100 X 10(9)/l) in 5, partial (platelet counts between 50 and 100 X 10(9)/l) in 6. In all these patients, the response was transient lasting 2-4 weeks. In 4 patients, no response was observed. We used plasmin-cleaved gammaglobulins which caused rare and mild side effects and gave results similar to those reported with intact human gammaglobulins. The indications of high dose i.v. gamma-globulins in the management of adult patients with autoimmune thrombocytopenic purpura are discussed.

摘要

我们报告了15例成年慢性自身免疫性血小板减少性紫癜患者接受大剂量静脉注射丙种球蛋白治疗的结果。11例患者经此治疗后病情缓解，其中5例完全缓解（血小板计数高于100×10⁹/L），6例部分缓解（血小板计数在50至100×10⁹/L之间）。在所有这些患者中，反应都是短暂的，持续2至4周。4例患者未观察到反应。我们使用了纤溶酶裂解的丙种球蛋白，其副作用罕见且轻微，结果与完整人丙种球蛋白报道的相似。讨论了大剂量静脉注射丙种球蛋白在成年自身免疫性血小板减少性紫癜患者治疗中的应用指征。