Jahn U, Adrian R W, Ismail S, Michos N
Arzneimittelforschung. 1983;33(5):726-39.
It has been shown, in extensive animal experiments, that 1-(omega-dimethylaminoethylmethyl)-amino-3-phenylindole hydrochloride (binodaline HCl, Sgd-Scha 1059), can be regarded as an antidepressant with novel characteristics. With anticholinergic and histamine-antagonistic effects almost completely lacking, the main effects of binodaline HCl are to increase noradrenergic influences and to produce CNS depression. The acute toxicity of binodaline HCl is comparatively low, and the good tolerance has been demonstrated in long-term studies in laboratory animals.
大量动物实验表明，1-（ω-二甲基氨基乙基甲基）-氨基-3-苯基吲哚盐酸盐（盐酸比诺达林，Sgd-Scha 1059）可被视为一种具有新特性的抗抑郁药。盐酸比诺达林几乎完全没有抗胆碱能和组胺拮抗作用，其主要作用是增强去甲肾上腺素能影响并产生中枢神经系统抑制。盐酸比诺达林的急性毒性相对较低，并且在实验室动物的长期研究中已证明其耐受性良好。
