Zagoren J C, Politis M J, Spencer P S
Brain Res. 1983 Jun 27;270(1):162-4. doi: 10.1016/0006-8993(83)90807-7.
Microtubules and neurofilaments are the major components of nerve fiber axoplasm and are evenly distributed longitudinally. Rearrangement of this distribution can be induced by a number of chemicals, including 2,5-hexanedione (2,5-HD). Utilizing 2,5-HD, this study explores the earliest time points of observable rearrangement of the cytoskeletal elements. Intrafascicular injections into the sciatic nerve shows central accumulation of microtubules and peripheral relocation of neurofilaments within 1 min of injection, suggesting a direct effect of the toxin on these components.
微管和神经丝是神经纤维轴浆的主要成分，并沿纵向均匀分布。这种分布的重排可由多种化学物质诱导，包括2,5 -己二酮（2,5 - HD）。本研究利用2,5 - HD探索细胞骨架成分可观察到重排的最早时间点。坐骨神经束内注射显示，注射后1分钟内微管向中央聚集，神经丝向周边移位，提示毒素对这些成分有直接作用。
