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胰岛激活蛋白（IAP）对大鼠输精管收缩反应的影响：Ni（抑制性GTP结合调节蛋白）参与α2-肾上腺素能受体介导反应的证据。

Effect of islet-activating protein (IAP) on contractile responses of rat vas deferens: evidence for participation of Ni (inhibitory GTP binding regulating protein) in the alpha 2-adrenoceptor-mediated response.

作者信息

Lai R T, Watanabe Y, Yoshida H

出版信息

Eur J Pharmacol. 1983 Jun 17;90(4):453-6. doi: 10.1016/0014-2999(83)90572-1.

DOI:10.1016/0014-2999(83)90572-1
PMID:6684057
Abstract

The effects of islet-activating protein (IAP) on the contractile responses of vas deferens to exogenous norepinephrine (NE) and electric stimulation (ES) were investigated. IAP treatment had no effect on the contractile response to NE. Pretreatment of the vas deferens with IAP (2.0 micrograms/ml) for 2 h however significantly attenuated the inhibitory effect of clonidine on ES-induced contractile responses, suggesting that feedback inhibition of presynaptic alpha 2-adrenoceptors is mediated by the Ni subunit of presynaptic adenylate cyclase.

摘要

研究了胰岛激活蛋白（IAP）对输精管对外源性去甲肾上腺素（NE）和电刺激（ES）的收缩反应的影响。IAP处理对NE的收缩反应没有影响。然而，用IAP（2.0微克/毫升）预处理输精管2小时，可显著减弱可乐定对ES诱导的收缩反应的抑制作用，这表明突触前α2-肾上腺素能受体的反馈抑制是由突触前腺苷酸环化酶的Ni亚基介导的。

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1
Effect of islet-activating protein (IAP) on contractile responses of rat vas deferens: evidence for participation of Ni (inhibitory GTP binding regulating protein) in the alpha 2-adrenoceptor-mediated response.胰岛激活蛋白（IAP）对大鼠输精管收缩反应的影响：Ni（抑制性GTP结合调节蛋白）参与α2-肾上腺素能受体介导反应的证据。
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引用本文的文献

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Field stimulation-induced noradrenaline release from guinea-pig atria is modulated by prejunctional alpha 2-adrenoceptors and protein kinase C.豚鼠心房的场刺激诱导去甲肾上腺素释放受突触前α2-肾上腺素能受体和蛋白激酶C的调节。
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N-ethylmaleimide (NEM) diminishes alpha 2-adrenoceptor mediated effects on noradrenaline release.
N-乙基马来酰亚胺（NEM）可减弱α2-肾上腺素能受体介导的去甲肾上腺素释放效应。
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