Lefkowitch J H, Rushton A R, Feng-Chen K C
Gastroenterology. 1983 Oct;85(4):951-7.
The light- and electron-microscopic changes in a biopsy of the liver obtained at age 17 mo from a child with fetal alcohol syndrome were studied. At the time of biopsy, hepatomegaly and raised serum transaminases were present as well as neurologic and growth defects and the typical facial anomalies seen in this syndrome. Light microscopy of the liver biopsy specimen revealed parenchymal fat with portal and perisinusoidal fibrosis. Ultrastructurally, perisinusoidal spaces contained deposits of intermediate-size and large collagen fibers, myofibroblasts and occasional Ito cells, and subendothelial basement membrane-like material. These changes resemble those seen in adult human and baboon alcoholic liver disease and suggest that hepatic fibrosis in fetal alcohol syndrome has a similar pathogenesis.
对一名17个月大患有胎儿酒精综合征儿童的肝脏活检组织进行了光镜和电镜检查。活检时，患儿存在肝肿大、血清转氨酶升高，以及该综合征特有的神经和生长缺陷及典型面部异常。肝脏活检标本的光镜检查显示实质脂肪伴门脉和窦周纤维化。超微结构上，窦周间隙含有中等大小和粗大的胶原纤维沉积物、肌成纤维细胞及偶尔的贮脂细胞，以及内皮下类似基底膜的物质。这些变化与成人及狒狒酒精性肝病所见相似，提示胎儿酒精综合征中的肝纤维化具有相似的发病机制。
