Morphine pretreatment reduces clomipramine effect in mouse forced-swimming test.
作者信息
Eschalier A, Rigal F, Devoize J L, Trolese J F, Grillon C
出版信息
Eur J Pharmacol. 1983 Aug 5;91(4):505-7. doi: 10.1016/0014-2999(83)90177-2.
PMID:6684579
Abstract
It had previously been shown that naloxone inhibits the effect of clomipramine both in a pain test in the forced-swimming test in mice which is proposed as an antidepressant study model. Evidence is reported of a decrease in activity of clomipramine in the forced-swimming test in mice after morphine pretreatment. The hypothesis of an interaction with mu-opiate receptors is considered.
摘要
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