边缘下丘脑系统损伤对家兔肾上腺皮质对每日重复热暴露反应的影响。
Influence of lesions of the limbic-hypothalamic system on adrenocortical responses to daily repeated heat exposures in rabbits.
作者信息
Seto K, Kaba H, Saito H, Edashige N, Kawakami M
出版信息
Exp Clin Endocrinol. 1983 Jul;82(1):42-50. doi: 10.1055/s-0029-1210254.
The effects of lesions in the basal medial hypothalamus and limbic structure upon the responses of adrenocorticoids formation in adrenal slices of rabbits to daily repeated heat exposures has been investigated. (1) The adrenocortical responses to heat exposure on the 1st day were decreased by lesions in the periventricular arcuate nucleus (ARC), ventromedial hypothalamus (VMH), stria terminalis (ST) and dorsal fornix (FX). (2) There were no effects of heat exposure on the 10th day upon the adrenocorticoid formation in either the sham-lesioned rabbits or the rabbits with the lesions of ARC, VMH and ST. (3) In rabbits with the FX lesions, the adrenocorticoids formation was significantly increased by heat exposure on the 10th day. (4) These results suggested that the basal medial hypothalamus, amygdala (AMYG)-ST system and dorsal hippocampus (HPC)-FX system participated in the mechanisms of adrenocortical responses to heat exposure on the 1st day, but only the HPC-FX system played some roles in complete disappearance process of adrenocortical responses to heat exposure by repetition of exposures.
研究了家兔下丘脑基底部内侧及边缘结构损伤对其肾上腺切片中肾上腺皮质激素形成对每日重复热暴露反应的影响。（1）在第1天，室周弓状核（ARC）、腹内侧下丘脑（VMH）、终纹床核（ST）和穹窿背侧（FX）损伤会降低肾上腺皮质对热暴露的反应。（2）在第10天，热暴露对假手术家兔或ARC、VMH和ST损伤的家兔的肾上腺皮质激素形成均无影响。（3）在FX损伤的家兔中，第10天热暴露会使肾上腺皮质激素形成显著增加。（4）这些结果表明，下丘脑基底部内侧、杏仁核（AMYG）-ST系统和背侧海马（HPC）-FX系统参与了第1天肾上腺皮质对热暴露的反应机制，但只有HPC-FX系统在重复热暴露导致肾上腺皮质对热暴露反应完全消失的过程中发挥了一定作用。
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