Bichler E, Daxenbichler G, Marth C
Oncology. 1983;40(5):336-9. doi: 10.1159/000225757.
The serum levels of retinol, RBP (retinol-binding protein) and PALB (prealbumin) were found to be significantly lower in patients with malignant tumors of the head and neck region than in controls. In tumor tissues as well as in normal laryngeal mucosa, specific binding sites for retinol and retinoic acid were found. Whereas retinol-binding (CRBP = cellular retinol-binding protein) could only be detected in a few cases, binding for retinoic acid (CRABP = cellular retinoic acid-binding protein) was present in all specimens investigated. The presence or lack of binding sites was not dependent on the actual serum retinol levels. With regard to the antineoplastic role of vitamin A, the reduced serum levels are considered as a possible factor in tumor development and growth. CRBP and CRABP are assumed to be mediating factors for the retinol and retinoic acid action. Since the presence of CRABP is a constant finding, we propose that retinoic acid and its synthetic derivatives with high affinity for CRABP could be appropriate antineoplastic drugs in these tissues.
研究发现，头颈部恶性肿瘤患者血清中的视黄醇、视黄醇结合蛋白（RBP）和前白蛋白（PALB）水平显著低于对照组。在肿瘤组织以及正常喉黏膜中，均发现了视黄醇和视黄酸的特异性结合位点。虽然仅在少数病例中检测到视黄醇结合（CRBP = 细胞视黄醇结合蛋白），但在所有研究标本中均存在视黄酸结合（CRABP = 细胞视黄酸结合蛋白）。结合位点的存在与否并不取决于实际血清视黄醇水平。关于维生素A的抗肿瘤作用，血清水平降低被认为是肿瘤发生和生长的一个可能因素。CRBP和CRABP被假定为视黄醇和视黄酸作用的介导因子。由于CRABP的存在是一个恒定的发现，我们提出，对视黄酸及其对CRABP具有高亲和力的合成衍生物可能是这些组织中合适的抗肿瘤药物。
