Archer T, Mohammed A K, Ross S B, Söderberg U
Pharmacol Biochem Behav. 1983 Jul;19(1):121-30. doi: 10.1016/0091-3057(83)90320-9.
Following systemic administration of the noradrenaline (NA) neurotoxin, DSP4 (50 mg/kg), rats were found to be retarded in the rate at which they acquired the "right-turn" running response in a modified T-maze choice situation, as measured by the total number of errors per session and median latency to reach the goal box. Desipramine (DMI, 20 mg/kg), injected 30 min before DSP4 blocked the acquisition retardation. DSP4 was found to have a short-lasting effect upon spontaneous motor activity, while food and water intake recovery was complete within 7 days of the injection. Both the NA-accumulation data and endogenous NA concentrations indicated profound NA, but not 5-hydroxytryptamine (5-HT) and dopamine (DA), depletions in the cortex, hippocampus and cerebellum. These data seem to confirm the role of the locus coeruleus-noradrenaline (LC-NA) system in an instrumental learning situation.
在对大鼠系统性给予去甲肾上腺素（NA）神经毒素DSP4（50毫克/千克）后，发现在改良的T迷宫选择情境中，大鼠获得“右转”奔跑反应的速度有所迟缓，这通过每次实验的错误总数和到达目标箱的中位潜伏期来衡量。在DSP4注射前30分钟注射的地昔帕明（DMI，20毫克/千克）可阻止获得性迟缓。发现DSP4对自发运动活动有短期影响，而食物和水摄入量在注射后7天内完全恢复。NA积累数据和内源性NA浓度均表明，皮质、海马体和小脑中的NA显著耗竭，但5-羟色胺（5-HT）和多巴胺（DA）未受影响。这些数据似乎证实了蓝斑-去甲肾上腺素（LC-NA）系统在工具性学习情境中的作用。
