Dudek B C, Phillips T J
Subst Alcohol Actions Misuse. 1983;4(1):31-6.
Methanol, ethanol, t-butanol and pentobarbital all produced marked dose dependent activation of locomotor activity in Short-Sleep mice which were selectively bred for relative insensitivity to the hypnotic properties of ethanol. The locomotor activity of alcohol sensitive Long-Sleep mice was depressed in a dose dependent fashion by all four drugs. Simultaneous assessment of intoxication in a grid test indicated that all four drugs disrupted coordination, in a dose dependent manner, to a greater degree in Long-Sleep mice than in Short-Sleep mice. The line differences in response to all alcohols was greater than for pentobarbital, indicating that the previous assumption of specificity of the selection for alcohols may be a question of degree rather than a qualitative effect.
甲醇、乙醇、叔丁醇和戊巴比妥均能使短睡眠小鼠的自发活动产生显著的剂量依赖性激活，这些小鼠是为对乙醇催眠特性相对不敏感而选择性培育的。对酒精敏感的长睡眠小鼠的自发活动则会被这四种药物以剂量依赖性方式抑制。在网格试验中对中毒情况进行同步评估表明，这四种药物均以剂量依赖性方式破坏协调性，在长睡眠小鼠中比在短睡眠小鼠中破坏程度更大。对所有醇类反应的品系差异大于对戊巴比妥的差异，这表明先前关于醇类选择特异性的假设可能是程度问题而非定性效应。
