Nikulina E M, Popova N K
Zh Vyssh Nerv Deiat Im I P Pavlova. 1983 Jul-Aug;33(4):737-42.
The study was devoted to the influence of serotonin (5-HT) on the mice predatory aggression towards locusts which was estimated by the latency of attack and the number of aggressive mice in the experimental group. 10 mg/kg of 5-HT injected intraperitoneally, significantly decreased the percentage of aggressive mice and prolonged the attacks latency. 5-Hydroxytryptophan (5-HTP), 5-HT precursor, had a more prominent inhibitory effect which was significant when the dose amounted to 50 mg/kg. Imipramin, an inhibitor of 5-HT reuptake, diminished predatory aggression in dose-dependent manner. Pretreatment of metisergid (blockader of 5-HT receptors) prevented the inhibitory effect of 5-HTP. 5-HT suppressing influence on mice predatory aggression is due by its action on central mechanisms as the injection of small doses of 5-HT in the mice lateral ventricle considerably decreased their aggression towards locusts.
该研究致力于探讨血清素（5-羟色胺，5-HT）对小鼠捕食蝗虫的攻击行为的影响，通过攻击潜伏期和实验组中有攻击行为的小鼠数量来评估。腹腔注射10mg/kg的5-HT，显著降低了有攻击行为的小鼠的百分比，并延长了攻击潜伏期。5-羟色氨酸（5-HTP），5-HT的前体，具有更显著的抑制作用，当剂量达到50mg/kg时具有显著性。丙咪嗪，一种5-HT再摄取抑制剂，以剂量依赖的方式减少捕食性攻击行为。美西麦角（5-HT受体阻断剂）预处理可阻止5-HTP的抑制作用。5-HT对小鼠捕食性攻击行为的抑制作用是由于其对中枢机制的作用，因为向小鼠侧脑室注射小剂量的5-HT可显著降低它们对蝗虫的攻击性。
