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1
The human erythrocyte nucleoside and glucose transporters are both band 4.5 membrane polypeptides.人类红细胞核苷转运体和葡萄糖转运体均为4.5带膜多肽。
Biochem J. 1983 Sep 15;214(3):995-7. doi: 10.1042/bj2140995.
2
Identification of glucose and nucleoside transport proteins in neonatal pig erythrocytes using monoclonal antibodies against band 4.5 polypeptides of adult human and pig erythrocytes.利用抗成人及猪红细胞4.5带多肽的单克隆抗体鉴定新生猪红细胞中的葡萄糖和核苷转运蛋白。
Biochem Cell Biol. 1988 Aug;66(8):839-52. doi: 10.1139/o88-096.
3
Proteolytic cleavage of [3H]nitrobenzylthioinosine-labelled nucleoside transporter in human erythrocytes.人红细胞中[3H]硝基苄硫肌苷标记的核苷转运体的蛋白水解切割
Biochem J. 1985 Sep 15;230(3):777-84. doi: 10.1042/bj2300777.
4
Chromatographic characterization of nitrobenzylthioinosine binding proteins in band 4.5 of human erythrocytes: purification of a 40 kDa truncated nucleoside transporter.人红细胞4.5带中硝基苄基硫代肌苷结合蛋白的色谱表征：一种40 kDa截短核苷转运蛋白的纯化
Biochim Biophys Acta. 1990 Oct 19;1028(3):251-60. doi: 10.1016/0005-2736(90)90174-m.
5
Identification of the erythrocyte nucleoside transporter as a band 4.5 polypeptide. Photoaffinity labeling studies using nitrobenzylthioinosine.将红细胞核苷转运体鉴定为4.5带多肽。使用硝基苄硫肌苷的光亲和标记研究。
J Biol Chem. 1983 Nov 25;258(22):13745-51.
6
5'-S-(2-aminoethyl)-N6-(4-nitrobenzyl)-5'-thioadenosine (SAENTA), a novel ligand with high affinity for polypeptides associated with nucleoside transport. Partial purification of the nitrobenzylthioinosine-binding protein of pig erythrocytes by affinity chromatography.5'-S-(2-氨基乙基)-N6-(4-硝基苄基)-5'-硫代腺苷（SAENTA），一种对与核苷转运相关的多肽具有高亲和力的新型配体。通过亲和色谱法对猪红细胞的硝基苄基硫代肌苷结合蛋白进行部分纯化。
Biochem J. 1990 Sep 15;270(3):605-14. doi: 10.1042/bj2700605.
7
Kinetics of nitrobenzylthioinosine binding to the human erythrocyte nucleoside transporter.硝基苄基硫代肌苷与人红细胞核苷转运体结合的动力学
Biochem J. 1983 Dec 15;216(3):661-7. doi: 10.1042/bj2160661.
8
Extraction and partial purification of the nucleoside-transport system from human erythrocytes based on the assay of nitrobenzylthioinosine-binding activity.基于对硝基苄硫代肌苷结合活性的测定，从人红细胞中提取和部分纯化核苷转运系统。
Biochem J. 1981 Jan 15;194(1):331-9. doi: 10.1042/bj1940331.
9
Characterization of monoclonal antibodies that recognize band 4.5 polypeptides associated with nucleoside transport in pig erythrocytes.识别与猪红细胞核苷转运相关的4.5带多肽的单克隆抗体的特性分析
Biochem J. 1987 Jun 15;244(3):749-55. doi: 10.1042/bj2440749.
10
Cytochalasin B. A natural photoaffinity ligand for labeling the human erythrocyte glucose transporter.细胞松弛素B。一种用于标记人类红细胞葡萄糖转运蛋白的天然光亲和配体。
J Biol Chem. 1982 Jul 10;257(13):7290-3.

引用本文的文献

1
ADP modifies the function of the glucose transporter: studies with reconstituted liposomes.ADP改变葡萄糖转运蛋白的功能：重组脂质体研究
Biochem J. 1993 Jun 15;292 ( Pt 3)(Pt 3):877-81. doi: 10.1042/bj2920877.
2
Photoaffinity labelling of nucleoside-transport proteins in plasma membranes isolated from rat and guinea-pig liver.从大鼠和豚鼠肝脏分离的质膜中核苷转运蛋白的光亲和标记
Biochem J. 1984 Jun 1;220(2):499-506. doi: 10.1042/bj2200499.
3
Proteolytic cleavage of [3H]nitrobenzylthioinosine-labelled nucleoside transporter in human erythrocytes.人红细胞中[3H]硝基苄硫肌苷标记的核苷转运体的蛋白水解切割
Biochem J. 1985 Sep 15;230(3):777-84. doi: 10.1042/bj2300777.
4
Inhibition by nucleosides of glucose-transport activity in human erythrocytes.核苷对人红细胞葡萄糖转运活性的抑制作用。
Biochem J. 1988 Jan 15;249(2):383-9. doi: 10.1042/bj2490383.
5
Erythrocyte nucleoside and sugar transport. Endo-beta-galactosidase and endoglycosidase-F digestion of partially purified human and pig transporter proteins.红细胞核苷与糖转运。部分纯化的人及猪转运蛋白的内切β-半乳糖苷酶和内切糖苷酶-F消化作用
Biochem J. 1986 Dec 1;240(2):349-56. doi: 10.1042/bj2400349.
6
Nucleoside transport in rat erythrocytes: two components with differences in sensitivity to inhibition by nitrobenzylthioinosine and p-chloromercuriphenyl sulfonate.大鼠红细胞中的核苷转运：对硝基苄硫基肌苷和对氯汞苯磺酸盐抑制作用敏感性不同的两个组分。
J Membr Biol. 1986;93(1):1-10. doi: 10.1007/BF01871013.
7
Possible multifunction of glucose transporter. Transport of nicotinamide by reconstituted liposomes.葡萄糖转运体的可能多功能性。重组脂质体对烟酰胺的转运。
Biochem J. 1992 Dec 1;288 ( Pt 2)(Pt 2):669-74. doi: 10.1042/bj2880669.

本文引用的文献

1
Nucleoside transport in human erythrocytes. Apparent molecular weight of the nitrobenzylthioinosine-binding complex estimated by radiation-inactivation analysis.人红细胞中的核苷转运。通过辐射失活分析估算的硝基苄硫代肌苷结合复合物的表观分子量。
Biochem J. 1980 Aug 15;190(2):373-6. doi: 10.1042/bj1900373.
2
Extraction and partial purification of the nucleoside-transport system from human erythrocytes based on the assay of nitrobenzylthioinosine-binding activity.基于对硝基苄硫代肌苷结合活性的测定，从人红细胞中提取和部分纯化核苷转运系统。
Biochem J. 1981 Jan 15;194(1):331-9. doi: 10.1042/bj1940331.
3
Cytochalasin B. A natural photoaffinity ligand for labeling the human erythrocyte glucose transporter.细胞松弛素B。一种用于标记人类红细胞葡萄糖转运蛋白的天然光亲和配体。
J Biol Chem. 1982 Jul 10;257(13):7290-3.
4
Photoaffinity labeling of the human erythrocyte D-glucose transporter.人类红细胞D-葡萄糖转运蛋白的光亲和标记
J Biol Chem. 1982 May 25;257(10):5419-25.
5
Photoaffinity labeling of the human erythrocyte nucleoside transporter by N6-(p-Azidobenzyl)adenosine and nitrobenzylthioinosine. Evidence that the transporter is a band 4.5 polypeptide.用N6-（对叠氮苄基）腺苷和硝基苄硫基肌苷对人红细胞核苷转运体进行光亲和标记。证明该转运体是一种4.5带多肽。
J Biol Chem. 1983 Feb 25;258(4):2202-8.
6
Nucleoside transport in animal cells.动物细胞中的核苷转运
Biosci Rep. 1983 Apr;3(4):309-22. doi: 10.1007/BF01122895.
7
Reconstitution and purification of the D-glucose transporter from human erythrocytes.人红细胞D-葡萄糖转运蛋白的重组与纯化。
J Biol Chem. 1977 Oct 25;252(20):7384-90.

人类红细胞核苷转运体和葡萄糖转运体均为4.5带膜多肽。

The human erythrocyte nucleoside and glucose transporters are both band 4.5 membrane polypeptides.

作者信息

Wu J S, Jarvis S M, Young J D

出版信息

Biochem J. 1983 Sep 15;214(3):995-7. doi: 10.1042/bj2140995.

DOI:10.1042/bj2140995
PMID:6684920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1152343/
Abstract

Human erythrocyte membranes and partially purified nucleoside transporter (band 4.5 and 7) were photoaffinity labelled with 3H-labelled 6-[(4-nitrobenzyl)thio]-9-beta-D-ribofuranosylpurine under equilibrium binding conditions. Band 4.5 was the major site of radiolabelling in both preparations. These experiments provide additional evidence to implicate band 4.5 polypeptides in nucleoside permeation, proteins previously shown to be involved in hexose transport.

摘要

在平衡结合条件下，用人红细胞膜和部分纯化的核苷转运体（4.5带和7带）与3H标记的6-[(4-硝基苄基)硫基]-9-β-D-呋喃核糖基嘌呤进行光亲和标记。在两种制剂中，4.5带都是放射性标记的主要位点。这些实验提供了额外的证据，表明4.5带多肽参与核苷通透，此前已证明这些蛋白质参与己糖转运。