Ducket S, Hiller D, Ballas S K
Neurotoxicology. 1983 Summer;4(2):227-34.
A single dose of 204Tl, representing about 2-3 ng 204Tl per gm/wt was injected into young and adult rats. Rats were killed daily over a period of 10 days and the levels of Tl were estimated in nervous and other tissues. The greatest concentrations of Tl (peak concentration time - PCT) in all tissues in the adult rat occurred 24 hours after injection. In the young rat PCT in the sciatic nerve and spinal cord were 48 hours after injection whereas it occurred 24 hours after injection in the brain and somatic organs. There were differences in biological half-lives of the organs in the young as compared to the adult rats. Tl level in all organs except the kidney, were about 2 pg/mg of tissue. It was concentrated in the cytoplasm of most cells examined. Tl levels then fell rapidly during the few days following the injection, and slowly afterwards. Thirty days after the injection, tracts of 204Tl were present in the cytoplasm of nervous and somatic cells.
将单剂量的204Tl（相当于每克体重约2 - 3纳克204Tl）注射到幼年和成年大鼠体内。在10天的时间里，每天处死大鼠，并对神经组织和其他组织中的铊含量进行估算。成年大鼠所有组织中铊的最大浓度（峰值浓度时间 - PCT）在注射后24小时出现。幼年大鼠坐骨神经和脊髓中的PCT在注射后48小时出现，而在大脑和躯体器官中则在注射后24小时出现。与成年大鼠相比，幼年大鼠各器官的生物半衰期存在差异。除肾脏外，所有器官中的铊含量约为2皮克/毫克组织。它集中在所检查的大多数细胞的细胞质中。注射后的几天内，铊含量迅速下降，之后下降缓慢。注射30天后，神经细胞和体细胞的细胞质中仍存在204Tl的痕迹。
