Garris D R, Curry T E
Proc Soc Exp Biol Med. 1983 Nov;174(2):198-204. doi: 10.3181/00379727-174-41725.
The relationships of ovarian blood flow (OBF) to ovarian function, body weight, cyclic state, and age of the corpus luteum were studied in aging rats with acutely implanted electromagnetic blood flow probes. Ovarian function was monitored by estimation of serum 17-beta-estradiol (E2) and progesterone (P) levels during (i) different stages of body maturation as indexed by body weight, and (ii) various stages of the estrous and pseudopregnancy (PSP) cycles. A distinct elevation in basal OBF rates was observed to occur in relation to body weight/age. Basal OBF rates and body weight exhibited a near linear correlation (r = 0.985; P less than or equal to 0.001) between 200 and 260 g, with a rise in mean basal OBF rates from 1.1 to 3.2 ml/min occurring in Day-8 PSP rats (Day 0 = ovulation). In weight-regulated (greater than or equal to 250 g) cycle rats, OBF increased in parallel with serum E2 levels during the proestrus-estrus period in association with ovulation, and subsequently declined to basal levels on diestrus. In PSP rats, OBF remained elevated between Days 1 and 8, during the period of peak luteal function. Between Days 8 and 12, both OBF and luteal function declined in a parallel manner as the ovary prepared for the subsequent ovulatory period. These results indicate that during the estrous cycle, OBF rates and serum E2 levels rise in a parallel manner, whereas during PSP, serum P levels and OBF are positively correlated. The parallel decline in OBF and serum P during luteolysis suggest that both parameters are functionally related and may be regulated by either a systemic or intraovarian controlling mechanism.
采用急性植入电磁血流探头的方法，在衰老大鼠中研究了卵巢血流（OBF）与卵巢功能、体重、周期状态及黄体年龄之间的关系。通过在（i）以体重为指标的身体成熟不同阶段，以及（ii）动情周期和假孕（PSP）周期的各个阶段，测定血清17-β-雌二醇（E2）和孕酮（P）水平来监测卵巢功能。观察到基础OBF率随体重/年龄有明显升高。在200至260克之间，基础OBF率与体重呈现近乎线性的相关性（r = 0.985；P≤0.001），在第8天PSP大鼠（第0天=排卵）中，平均基础OBF率从1.1毫升/分钟升至3.2毫升/分钟。在体重调节（≥250克）的周期大鼠中，在发情前期-发情期与排卵相关时，OBF与血清E2水平平行升高，随后在间情期降至基础水平。在PSP大鼠中，在黄体功能高峰期的第1至8天，OBF保持升高。在第8至12天，随着卵巢为随后的排卵期做准备，OBF和黄体功能以平行方式下降。这些结果表明，在动情周期中，OBF率和血清E2水平平行升高，而在PSP期间，血清P水平与OBF呈正相关。黄体溶解期间OBF和血清P的平行下降表明这两个参数在功能上相关，可能受全身或卵巢内控制机制调节。
