Randall C L, Hughes S S, Williams C K, Anton R F
Pharmacol Biochem Behav. 1983;18 Suppl 1:325-9. doi: 10.1016/0091-3057(83)90194-6.
An animal model was used to examine the effect of maternal alcohol administration on behaviors in the offspring which might predispose to alcoholism. Pregnant C3H mice were administered a liquid diet containing 28% ethanol-derived calories (EDC) from Gestation-Day 8 until parturition. Control animals were either pair-fed an isocaloric 0% EDC diet or received standard lab chow and water throughout pregnancy. Offspring were tested for sleep time following a challenge dose of 3.5 or 4.5 g/kg ethanol at 25 or 110 days of age or for consumption of 10% w/v ethanol in a two-bottle choice situation. The results demonstrated that prenatal exposure to alcohol did not affect alcohol-induced sleep time at either testing age or dose and that waking blood alcohol levels were similar across groups. Voluntary alcohol consumption, however, was higher in mice exposed to alcohol in utero during the initial week of testing but intake decreased to near control levels by the third week. Whether other alcohol-related behaviors are altered by prenatal alcohol exposure remains to be examined.
使用动物模型来研究母体给予酒精对后代可能易患酒精中毒行为的影响。怀孕的C3H小鼠从妊娠第8天到分娩期间给予含有28%乙醇衍生热量（EDC）的液体饮食。对照动物要么配对喂食等热量的0% EDC饮食，要么在整个怀孕期间接受标准实验室饲料和水。在25或110日龄时，给后代注射3.5或4.5 g/kg乙醇的挑战剂量后测试睡眠时间，或者在双瓶选择情况下测试10% w/v乙醇的消耗量。结果表明，产前暴露于酒精在任何测试年龄或剂量下均不影响酒精诱导的睡眠时间，且各组清醒时的血液酒精水平相似。然而，在测试的第一周，子宫内暴露于酒精的小鼠自愿饮酒量较高，但到第三周摄入量降至接近对照水平。产前酒精暴露是否会改变其他与酒精相关的行为仍有待研究。
