Abu-Murad C, Nordmann R
Pharmacol Biochem Behav. 1983;18 Suppl 1:515-7. doi: 10.1016/0091-3057(83)90228-9.
Male Swiss mice, when exposed to increasing concentrations of ethanol vapor for a period of 9 days, developed tolerance to as well as physical dependence on ethanol. Desferrioxamine, an iron-chelator and a lipid peroxidation inhibitor, administered to individual mice at a daily dose of 350 mg/kg body weight, caused a reduction in the degree of dependence but not of tolerance. Also, desferrioxamine protected the mice against the reduction in body weight increment observed over the inhalation period. It is suggested that desferrioxamine acts either via inhibiting the ethanol-induced lipid peroxidation, suspected to be involved in dependence, or via a different iron-sensitive mechanism.
雄性瑞士小鼠在9天内暴露于浓度不断增加的乙醇蒸气中后，会对乙醇产生耐受性和身体依赖性。去铁胺是一种铁螯合剂和脂质过氧化抑制剂，以每天350毫克/千克体重的剂量给予个体小鼠，会使依赖程度降低，但不会降低耐受性。此外，去铁胺保护小鼠免受吸入期观察到的体重增加减少的影响。有人认为，去铁胺的作用机制要么是通过抑制疑似与依赖性有关的乙醇诱导的脂质过氧化，要么是通过不同的铁敏感机制。
